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Jinks JL, Fulker DW. Comparison of the biometrical genetical, MAVA, and classical approaches to the analysis of human behavior. Psychol Bull. May .
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Biometrical genetics with one or two loci II. The estimation of linkage | Heredity

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Deriving the Hardy-Weinberg equation. Testing the departure from the HWE. The HWE in case of multiple alleles, X-linked alleles, in autopoliploids.

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HW for two loci: gametic phase equilibrium. HWE and non-random mating: assortative e disassortative mating, outbreeding and inbreeding. Sewall Wright equilibrium. Effect of mutation on allele frequencies. HWE and rate of reversible and irreversible mutation.

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Migration: one-way migration, island model. Effect of migration on allele frequencies. Wahlund effect. Random genetic drift and its effect on metapopulation and subpopulations.

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F-statistics of Sewall Wright. Effective population size.

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Bottleneck and founder event. Gene flow in fragmented populations. Natural selection and adaptation: fitness and selection coefficients.


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General model of natural selection on HWE. Selection aganist the recessive and aganist the dominant. Overdominance and heterozygote advantage.

Biometrical Genetics: The Study of Continuous Variation

Interactions between the evolutionary forces. Part 2: Quantitative genetics Elements of statistics: mean, variance, standard deviation, standard error, correlation andregresson, Student's t-test; one-way and two-way analysis of variance. Cluster analysis: data matrix, coefficients of similarity distance and correlations; hierarchical single linkage, complete linkage, UPGMA and non hierarchical k-means. Mendelian basis of continuous variation.

Phenotipic and genotipic value. Environmental deviation.


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  7. Different types of gene actions. Population mean. Population variance, phenotipic, genotypic and environmental variance. Additive and non-additive genetic variance dominance and epistatic variance.

    enter site Breeding value. Estimating additive variance and heritability: offspring-parent regression, sibling analyses.